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We hypothesized that this antagonism could be mediated by the multidrug resistance protein 1 (MRP1, encoded by ABCC1 ), a membrane transporter protein of the ATP-binding cassette (ABC) transporter superfamily that is involved in the cellular efflux of multiple compounds, including chemotherapeutic agents 54

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The CDC estimates the per year incidence of DVT is 1 to 2/1000 people.[ref] An 11-fold increase in risk for someone who is homozygous for the variant would then indicate a 1 to 2% risk of DVT in a given year

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