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The primary hurdle for oral GLP-1s has always been the "peptide problem"large molecules are easily broken down in the stomach

The Phase 2 trial published in the New England Journal of Medicine showed up to 24.2% weight loss at 48 weeks

In APP/PS1 transgenic mice, (D-Ser2)Oxm, a dual GLP-1 and Gcg receptor agonist, notably improves spatial memory and synaptic plasticity, reduces A plaque deposition in the hippocampus, and modulates the PI3K/AKT1/GSK3 signaling pathway [84]

It is what allowed tirzepatide to outperform semaglutide on weight loss in SURPASS and SURMOUNT trials

Given all the ways that turmeric supports well-being, adding some to meals and smoothies is a smart step for overall health and wellness

However, public views on GLP-1 RAs, crucial for treatment uptake and adherence, have not been thoroughly explored