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It can be delivered directly into the affected site through the use of microneedles [ 51 ]

there is the potential for: Ischemic injury due to potent vasoconstrictor action and tissue hypoxia Mild bradycardia, probably as a reflex result of a rise in blood pressure Arrhythmias Anxiety Transient headache Respiratory difficulty Pharmacokinetics: When released from nerve terminals, its actions are primarily (75%) terminated by neuronal reuptake Diffusion and degredation by extracellualr COMT contribute to a lesser extent

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Artificial intelligence (AI)-based algorithms, such as those validated in 2023, shows higher sensitivity for detecting NPDR due to more pronounced microvascular lesions (99, 100)

With respect to the treatment of neurodegenerative diseases, the general pro-survival anti-apoptotic activity of HGF supports the use of HGF mimetics for treating neurodegenerative diseases including but not limited to Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS), etc

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