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However, it is banned by the World Anti-Doping Agency (WADA) for competitive athletes

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Closing the "Vitamin Add-On" Loophole For a long time, some pharmacies argued that adding Vitamin B12 or other ingredients created a "new" medication that wasn't a copy of the brand name

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Furthermore, the rapid clearance of transporters from the circulatory system may induce therapeutic failure owing to inadequate mucosal permeability, glomerular filtration, phagocytosis, and non-specific targeting, which must be considered during research design