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The levels of Tregs continued to increase 711-fold in middle-aged mice [93,94,95]

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Moreover, mTOR drives the expansion of CD4CD8 double-negative T cells and stimulates their production of IL-17A, thereby enhancing autoantibody generation [66]

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Ideally, the findings of the above animal experiments require validation in clinical settings, to determine whether metformin can be applied to treat OA in humans

This receptor-binding mechanism forms the foundation of how peptide signaling works