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Again, in the first study using FOXO4-DRI to induce apoptosis in senescent cells, the senescent cells were generated by irradiation or doxorubicin ( As shown in Figure 3, FOXO4-DRI pre-treatment is the dedifferentiation of chondrocytes during the in vitro expansion

An Updated Review of the Literature. Frontiers in Physiology

Clinical trials show moderate evidence for pain reduction over 8 to 24 weeks, particularly in aging populations

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Each occupies a distinct mechanistic and application niche, and the formulation considerations differ meaningfully between them