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[17] If NSAIDs are necessary, they should be used at the lowest effective dose for the shortest duration, and patients with renal impairment should seek medical advice before use

Emerging evidence also suggests that metformin promotes mitophagy and mitochondrial biogenesis, further limiting mtDNA release and neuroinflammation [206,207,208]

doi: 10.3803/EnM.2014.29.4.536 70 KrnerMStckliMWaserBReubiJC