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Peripheral oxyntomodulin reduces food intake and body weight gain in rats

Peroxidation of the lipid membrane under the action of hydroxyl radical has the effect of disrupting the calcium transport within the endoplasmic reticulum, decreasing its uptake and increasing its level in myocytes during dystole (4,5), leading to dysrhythmias

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doi: 10.1038/s41392-023-01400-z, 31

They reported losing 35 pounds overall but struggled with side effects at higher doses, including food aversion and an extremely sensitive gag reflex

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