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Cobalamin has a well-documented role in appetite pathway activation

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In particular, section 1833(t)(16)(G) of the Act provides that with respect to a non-opioid treatment for pain relief furnished on or after January 1, 2025, and before January 1, 2028, the Secretary shall not package payment for the non-opioid treatment for pain relief into payment for a covered OPD service (or group of services) and shall make an additional payment for the non-opioid treatment for pain relief as specified in clause (ii) of that section

The diet involves either injecting or ingesting the pregnancy hormone human chorionic gonadotropin, or hCG, in combination with an ultra low-calorie diet

The study highlights that treatment success depends on diagnosis, patient factors, and proper dose optimization