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The discovery of sodium-channel block as the major mechanism underlying antiarrhythmic effects of quinidine led to the development of class I antiarrhythmic agents such as flecainide and propafenone

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The mean age group affected are in their 3rd and 4th decade of life and there seems to be a predilection for females

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Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions

Researchers often use the COA to confirm the analytical method used, the reported purity percentage (e.g., HPLC area %), and whether the identity data aligns with expectations