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The movement disorder society evidence-based medicine review update: treatments for the non-motor symptoms of Parkinsons disease

A study from the Netherlands found the 25th to 75th percentile among people 65 to be 180 to 300 nmol/l (van Wijngaarden, 2017)

Most published data derive from small pilot studies, in vitro experiments, and animal research, which substantially limits the conclusions that can be drawn

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The clinical translation of these trial results, which will be important for the comparison of GLP-1RAs with SGLT2 inhibitors in the treatment of patients with heart failure and a preserved ejection fraction, remains to be determined