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The copper ion stabilizes the peptide structure, facilitates cellular uptake, and participates directly in the enzymatic reactions that promote collagen synthesis and tissue remodeling

Vadhan-Raj S, Broxmeyer HE, Andreeff M , Bandres JC, Buescher ES, Benjamin RS, Papadopoulos NE, Burgess A, Patel S, Plager C, Hittelman WN, McAlister I, Garrison L, Williams DE

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and Pratt, D.A