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GLP-1 medications do not directly cause weight gain when used as prescribed

These are treatments delivered with precision and purpose

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The Combination: CagriSema The real clinical story is not monotherapy versus monotherapy it is the combination

The DAPA-CKD trial, for instance, demonstrated that dapagliflozin significantly reduced the risk of a composite outcome of sustained eGFR decline, end-stage kidney disease, or renal/cardiovascular death by 39% in patients with chronic kidney disease, with consistent benefits observed in participants with and without type 2 diabetes (Savedchuk et al., 2023)

Notably, a hyposialylated pro-proteinuric form of ANGPTL4 has been identified as a crucial contributor to fibrosis within diabetic kidneys