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TLRs can be localized either on the cell surface (TLR-1, -2, -4, -5, -6, -10) or in the endosome compartment (TLR-3, -7, -8, -9

demonstrated the topiramate linearity of the pharmacokinetics in plasma, while its clearance from whole blood seemed to increase with escalating doses (Shank et al., 2005)

ROS can activate the NF-B pathway by promoting the degradation of IBs, allowing NF-B to translocate into the nucleus and initiate gene transcription ( Figure 3 ) (97)

Depending on temperature, peptides can remain stable for 13 years

Proteostasis in cardiovascular health and disease Cardiovascular tissues, particularly the heart, operate under constant mechanical, metabolic and oxidative stress and therefore depend critically on robust proteostasis to sustain contractile function, bioenergetic efficiency and cellular survival

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