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doi: 10.1016/j.ssmph.2021.100731 36

Marked interindividual heterogeneity exists in platinum accumulation and toxicity severity among patients with similar cumulative doses, which is mainly mediated by genetic polymorphisms (e.g., GSTP1), epigenetic modifications, and baseline health status

Notably, the pathways of cysteine/methionine metabolism, nicotinate and nicotinamide metabolism, and purine metabolism are highlighted, with specific proteins and metabolites acting as central nodes

This strategy is called multimodal analgesia, and it is a standard protocol used in hospitals to manage acute pain without opioids

The lack of a bacterial growth inhibitor in sterile water mandates its disposal post a single use to avert microbial contamination

Joshua Berkowitz, our medical director, keeps up with the latest advancements in this field while prioritising the safety and efficacy of every treatment we provide