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Within these pathways, phospholipase C (PLC) is speculated to play a critical role by potentially catalyzing the formation of second messengers, such as inositol triphosphate (IP3) and diacylglycerol (DAG)

Impaired TCA cycle activity and reduced IDH3 exacerbate lactate accumulation, which increases lactylation and induces PAX6 expression, forming a positive feedback loop that promotes tau hyperphosphorylation, A accumulation, and synaptic dysfunction (Abdolmaleky et al., 2019

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Cleaning homes with harsh chemicals may contribute to respiratory issues independently of mold and is associated with the development of asthma in children

Combination naltrexone and bupropion reduces cravings by acting on brain reward pathways