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Chandys hypothesis, that the rapid onset of the repairing processes induced by B12 shots might overwhelm the system and temporarily cause a worsening in symptoms, similar to the Jarisch-Herxheimer reaction in those treated for Lyme disease

For most researchers, the two-compound stack represents a clean, manageable protocol without the complexity of managing multiple compounds simultaneously

Clin Rheumatol (2016) 35(9):218594

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Cytokine 136:155256 Ou J, Zhou Z, Dai R et al (2021) V367F mutation in SARS-CoV-2 spike RBD emerging during the early transmission phase enhances viral infectivity through increased human ACE2 receptor binding affinity