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However, head-to-head comparisons are limited, and individual patient responses vary considerably
Acknowledgements This work was supported by the Sichuan Science and Technology Program (Grant no
Consistent with these effects, GLP-1 RAs have been associated with substantial weight loss in clinical trials, leading to FDA approval of two of these agents liraglutide and semaglutide for chronic weight management in adults with obesity or with overweight and at least one weight-related comorbidity
Understanding the differences between diabetes indications, obesity indications, and secondary indications can significantly improve approval rates
Common side effects include nausea, vomiting, and constipation
This was true for semaglutide and liraglutide, among others
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