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ERS Clinical Practice Guidelines (2025): The European Respiratory Society updated its management guidelines, issuing a conditional recommendation for the use of mucoactive drugs like NAC in specific NCFB phenotypes, particularly those with high sputum production and frequent exacerbations (94)

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The structure showed the peptide clasped between the two domains and a sharp kink forming in the middle of transmembrane helix 6, which swings the receptors intracellular half outward to make room for the G protein

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