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Science 286 , 544548 (1999)

Overt folate deficiency is rare in countries with mandatory folic acid fortification programs, affecting less than 1 percent of the population

Misuse of either compound can also lead to serious health issues, such as hormonal imbalances and organ damage

The compounds were injected intraperitoneally over four cycles

Future surveillance frameworks should prioritize multinational data harmonization and integration with real-world evidence streams to enhance validity

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