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Within the central and peripheral nervous systems (CNS and PNS, respectively) the catecholamines exert their effects as neurotransmitters, in the periphery they do so as hormones

Athletes participating in endurance disciplinessuch as long-distance running, road cycling, and swimmingfrequently present with reduced bone mineral density relative to athletes from other sports, control groups, or established population norms

Data from longer-term treatment will therefore be eagerly awaited to determine the extent of body weight loss and metabolic outcomes and whether this is comparable to the latest GLP-1 mono-agonist therapies

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Post-renal: obstruction (stones, enlarged prostate, tumors)

Sitagliptin (Januvia) is a DPP4 inhibitor, and Semaglutide (Rybelsus) is a GLP-1 agonist