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All three components fall within the optimal molecular weight range (418900 Da) for efficient nasal mucosal absorption and direct nose-to-brain delivery, with each component independently studied for CNS penetration and neuroactive signaling

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Eur J Endocrinol (2008) 158:295303.10.1530/EJE-07-0562 29 FeroneDde HerderWWPivonelloRKrosJMvan KoetsveldPMde JongTet alCorrelation of in vitro and in vivo somatotropic tumor responsiveness to somatostatin analogs and dopamine agonists with immunohistochemical evaluation of somatostatin and dopamine receptors and electron microscopy

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Indeed, in the absence of bacteria, metformin shortened lifespan implying that it is the anti-bacterial action of metformin that explains the enhancement of lifespan in C