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Overall, these analyses indicate that while there may be trends in the data, demographic factors such as age and sex do not appear to significantly influence WL or WR outcomes following GLP-1RAs therapy or bariatric surgery

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TGF- is mediated by the transcription factor mothers against decapentaplegic homology (SMAD) that bind SMAD binding element (SBE) of target genes, regulating their expression [97]