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A recent systematic review reported pooled estimates of specificity of 72 and 82% for 18-fluorine fluorodeoxyglucose positron emission tomography and gadolinium MRI, respectively, underscoring the limitations of common diagnostic approaches for RN [92]

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Specifically, it has been reported that H 2 O 2 -dependent inactivation of autophagy-related gene-4 ( ATG4 ) increases LC3-associated autophagosomes and that ATM-mediated oxidation of AMP-activated protein kinase (AMPK) inhibits mammalian target of rapamycin 1 (TORC1), a pivotal negative regulator of autophagy 115,116,117 (Fig