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Proceedings of the National Academy of Sciences of the United States of America , 89 , 86418645 (United States, 1992)

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Nutrition & Metabolism,17 , 80

Subjects from the PIONNEER 7 study showed comparable satisfaction between oral semaglutide and sitagliptin [41], a dipeptidyl peptidase-4 inhibitor (DPP-4i) largely used in monotherapy or combination when first-line treatment does not achieve adequate glycaemic control, but sitagliptin does not provide any cardiovascular benefit [95]

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Collectively, these findings position GLP-1RAs as modulators of atherosclerotic disease beyond glycemic control, with integrated effects spanning systemic immunometabolism and plaque biology