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The slowed movement of food through the digestive system can lead to feelings of excessive fullness (early satiety), discomfort, and in some cases, nausea that persists between meals

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BTBR mice showed suppressed hippocampal neurogenesis, but curcumin restored progenitor proliferation and enhanced neural differentiation, suggesting that early curcumin exposure exerts long-lasting benefits (Zhong et al., 2020)

These findings suggest that the additional GCG agonism in cotadutide provides direct metabolic benefits to hepatocytes beyond those achievable through GLP-1 receptor activation alone, even when caloric restriction is matched [43]