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Federal spending is expected to increase under this demonstration due to paying for GLP-1s for obesity, which is not currently covered under Medicare, but the amount of the increase is unknown since CMS hasnt disclosed the projected cost

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GLP-1 receptor agonists work by mimicking the action of endogenous GLP-1, a hormone that stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and promotes satiety through central nervous system pathways

Obesity & body-weight regulation models: In vivo models exploring changes in body weight, adiposity, food intake and energy expenditure under Retatrutide-driven multi-agonist signaling