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Melena strongly suggests, and hematemesis confirms, that bleeding is of upper gastrointestinal originPeptic ulcer, the most common cause of gastrointestinal hemorrhage, should be pursued through questions about epigastric distress, the relationship of symptoms to food intake, and a history of peptic ulcer disease
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10.1038/sj.ejcn.1602138 Verhoef P, van Vliet T, Olthof MR, Katan MB: A high-protein diet increases postprandial but not fasting plasma total homocysteine concentrations: a dietary controlled, crossover trial in healthy volunteers
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Copper may become potential irritants when they are oxidized and causes the formation of free acids
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