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The most robust clinical evidence arguably originates from the large cardiovascular outcomes trials (CVOTs) completed for most GLP-1 RAs, of which the latest showed a significant relative risk reduction (RRR) of 39% (HR) with once-weekly efpeglenatide on HF requiring hospitalisation, corroborating a meta-analysis which found a significant RRR across eight GLP-1 RA CVOTs of 11%

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A slight modification in taste preferences or minor dry mouth, which can be effortlessly managed with consistent daily hydration

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Both medications are injectable treatments that have generated significant attention for their effectiveness, but they work in different ways and come with different considerations

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