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Additionally, gastrointestinal side effects common with GLP-1-based therapiesincluding nausea, vomiting, and diarrheamay reduce interest in sexual activity during the initial treatment period or dose escalation phases

Ethics declarations Competing interests MV has within the last three years, served as consultant for Lundbeck, Eli Lilly and Johnson & Johnson

The goal of skin lightening also referred to as skin bleaching, is to lower the skins melanin content

Is likely to have a negative effect on the skin and dry it out Helps to soften the upper layer of the skin Softens the upper layer of skin and helps restore the healthy skin barrier

10.2337/db06-1033 49

Therapeutic interventions that target adipocyte lipolysis Targeting adipocyte lipolysis for reducing obesity and improving insulin resistance has been of therapeutic interest for decades now (222)