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Although lowered, the changes observed in subjects treated with either repaglinide or metformin monotherapy were not significant for HbA1C (0.4 and 0.3% decrease, respectively), or fasting plasma glucose (9 mg/dl (0.5 mmol/l) increase and 5.4 mg/dl (0.3 mmol/l) decrease, respectively)

Reference: DAnnibale DA et al

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Semaglutide has been on the market for some time and has shown clinically significant weight loss results, earning it FDA approval under the brand name Wegovy

Whether someone is just starting GLP-1s or has been on them for a while, this guide explains what they might experience and how to help manage those symptoms

In 2024 the journal Diabetes named it as a classic paper