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For instance, combining myo-inositol with folic acid in PCOS patients modulates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation, reducing phosphorylated AKT levels and improving insulin sensitivity, a key factor in PCOS-associated infertility ( 5.2.1.2 Antioxidant synergy Optimizing antioxidant combinations, such as chlorogenic acid, curcumin, and -mercaptoethanol, may amplify protection against oxidative damage during embryo development

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These vitamins need to be absorbed on a daily basis for normal function

Its a challenge due to patients lack of adherence to long-term medication use, as well as difficulties in identifying poor blood pressure control and modifying therapy accordingly