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However, newer evidence suggests the relationship is more complex and that GIP activation in the context of GLP-1 activation might actually support fat burning

Glucagon-like peptide-1 evokes action potentials and increases cytosolic Ca 2+ in rat nodose ganglion neurons

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This is underscored by the results of a clinical trial comparing the development of obese adults who received either semaglutide or liraglutide in addition to nutritional advice and physical activity, and significantly greater weight loss was achieved in the semaglutide group [102]

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