therefore, prescribers usually restrict use to adults unless compelling justification exists
In human HT-1080 fibrosarcoma cells, treatment of erastin (Era) restricts the production of glutathione ( Supplementary Figure S13 ), and therefore inactivates GPX4 and triggers ferroptosis ( 102 prevented erastin-induced ferroptosis evidently in a dose-dependent manner ( Figure 8A ), even when the concentration of erastin reached to 100 M ( Figure 8B )
These conditions are examples, not a complete list
doi: 10.1007/s40265-019-01192-z 46 DuftonNHannonRBrancaleoneVDalliJPatelHBGrayMet al
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A., Mantella, R