Some researchers adjust timing or escalation speed based on body weight
This represents more than a research oversight
Lilly's triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial
Interestingly, in people with type 2 diabetes mellitus, who often exhibit glomerular hyperfiltration, GLP-1 receptor agonists stabilize or modestly reduce eGFR, an effect reminiscent of the initial declines observed with RAAS and SGLT2 inhibitors [64]
Tirzepatide treatment was not associated with excess cardiovascular risk (54, 74)
Unfortunately, most are given little guidance, risking issues like malnutrition, muscle loss, and fatigue as they lose weight