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The preclinical-to-clinical translation of this principle requires further validation, but the data are directionally consistent
doi: 10.1038/s41531-018-0058-0 85 YangWHamiltonJLKopilCBeckJCTannerCMAlbinRLet al
The mission of Noom is not to sell more meds, noted Cook
The main challenge is consistencyit only works if you actually use it regularly for months
Ok, now lets consider a scenario in which you already have a candidate interacting protein, and want to determine which part of it interacts with your protein of interest (Figure 6)
Within this framework, mitochondria are best understood as central interaction hubs for the ER, lysosomes, inflammasome platforms, and other organelles in PACs
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