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SCN may act on somatostatinergic neurons and GH-releasing hormones (GHRH) to synchronize the GH rhythm with the light-dark cycle (Willoughby and Martin, 1978

Patients who had either mild or moderate NPDR with DME at baseline were the most likely to experience worsening: 13 patients with mild NPDR and DME, and 16 patients with moderate NPDR and DME went on to develop PDR

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Nat Rev Mol Cell Biol 2009;10:63743

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(2015) Reaction of hydrogen sulfide with disulfide and sulfenic acid to form the strongly nucleophilic persulfide