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It works directly in areas of the brain involved in fullness and food reward, which may help reduce the drive to keep eating, not just how hungry you feel

Optimal dosing is also an open question

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As far as I can tell, the authors theory that red meat provides carnitine for bacteria to transform into TMA which our liver then converts to TMAO, which causes our macrophages to fill up with cholesterol, block our arteries, and cause heart attacks is just that: a theoryfull of sound and fury, signifying nothing

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The BBD was selected in this particular case since 3 factors were tested and it requires fewer runs than CCD for the same number of factors