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Platelet hyperactivity may be exacerbated by increased systemic inflammation, obesity, dyslipidemia, and other metabolic diseases (149)

36 Inclusion and exclusion criteria: To be included in the study, participants had to be older than 18 years at index date and 70 years or younger at start of follow-up, have 1 or more BMI assessments during the baseline period (year 1 and year 4), and a have mean BMI between 25 and 50 kg/m 2 during year 4 after the index date

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In human clinical trials, individuals ingesting ME-3 for two weeks gained a remarkable 49% increase in the ratio between reduced to oxidized glutathione