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80 weeks), and placebo response rates can fluctuate

GLP-1 medications primarily alter gastric function through delayed emptying and enhanced satiety signaling, not by causing the organ to physically shrink

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Retatrutide currently progresses through Phase 3 clinical trials, which typically require 18-24 months for completion plus additional time for FDA and Health Canada review

The same review notes the risk is higher for people on ACE inhibitors or ARBs, because those medicines change how your kidneys handle fluid loss