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The gradual dose escalation strategy specifically aims to improve tolerability by allowing the digestive system to adjust to the medication's effects on gastric emptying and satiety signaling

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Due to this high aerobic demand, the generation of high amounts of ROS and other oxidative by-products is unavoidable (Halliwell, 2006)

Questions arose regarding their efficacy in stable ischemic heart disease (IHD) without recent MI or heart failure

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Similar to GLP-1R signaling, GIPR activation also elevates intracellular cAMP levels, thereby enhancing glucose-dependent insulin secretion