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With respect to the aging process, insulin/IGF-1 signaling controls the activity of several longevity genes, such as mechanistic target of rapamycin (mTOR) and forkhead box O (FoxO) signaling [4, 5] (Fig

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Similarly, xanthine oxidase, an enzyme involved in purine metabolism, can generate superoxide and hydrogen peroxide as by-products, particularly under conditions of oxidative stress or tissue damage [48]

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