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Cruciani RA, Zhang JJ, Manola J, Cella D, Ansari B, Fisch MJ

This implies that GLP-1R is required for the control of heart rate in mice in the absence of pathology, but endogenous cardiomyocyte GLP-1R activity is not required for both adaptive responses to ischemic or cardiomyopathic injury and GLP-1 analogue-induced cardioprotection or enhanced chronotropic activity

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Avoid heavy drinking, especially during dose increases