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The main function of the AsA-GSH cycle originally observed was the detoxification of reactive oxygen species (ROS) in different subcellular compartments such as chloroplast, mitochondria, or cytosol

Subsequent animal studies have shown that mitochondrial heterogeneity can lead to a metabolic syndrome-like phenotype and adversely affect cognitive function

The pathogenesis of DN includes abnormal glucose metabolism, hyperperfusion and hyperfiltration of the kidney, oxidative stress, and inflammation

Cerebrolysin is a prescription pharmaceutical in many countries

Long-term use appears well-tolerated when dosing is appropriate and monitored