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Eng J 22(5):1330

Since estradiol levels were all the same in the osteoporotic, alendronate, and semaglutide groups, and the normalization of Ca 2+ level only occurred in alendronate and semaglutide, then it could only be concluded that semaglutide osteoprotective effects are separate from estradiol level

Furthermore, weight loss achieved using GIPR-Ab/GLP-1 was attenuated in mice with CNS loss of either Gipr or Glp-1r 61

Great summary and very important information to keep in mind for GLP-1 patient treatment

When IGF-1 is active, it behaves differently in different types of tissues

They should also include an analysis of potential interactions with conventional treatments and an assessment of KD's long-term safety in skin conditions