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Supplementation: Support patients with vitamin D, magnesium, zinc and sufficient protein to prevent muscle loss during weight reduction

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A polybasic stretch present in the N-terminal region of all G subunits has been implicated in PM binding 58

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In the Phase 2 trial protocol, participants reached the 12mg maximum dose at week 20 after five escalation steps (1mg, 2mg, 4mg, 8mg, 12mg), each held for four weeks