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They used a two compartments device, realizing a non-autologous supportive vascularized channel, obtained by seeding human umbilical vein endothelial cells (HUVECs), and an autologous hematopoietic channel with a 3D co-culture of human CD34 + cells and bone marrow-derived mesenchymal stromal cells (BMSCs) in a fibrin gel

Therefore, blood vitamin concentrations should be periodically monitored and the administration of additional therapeutic doses of Vitamin A may be required

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