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These endogenous gut hormones act on the central nervous system either via the circulation through areas deficient in the bloodbrain barrier, such as the median eminence of the hypothalamus and the area postrema [5] or via receptors of vagal afferents, together with stretch receptors and nutrient chemoreceptors [6]

Most commonly a combination of abdominal muscle stretching or separation during pregnancy and the C-section itself, excess skin that hasnt fully retracted, and postpartum hormonal and fluid changes

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Exendin-4 is a 39 amino acid peptide with 53% identity to GLP-1 (34) and is fully active at GLP-1 receptors and not degraded by DPP-4