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PP2A has been shown to be methylated by methyltransferase, leucine carboxyl methyltransferases 1 (LCMT-1) [168] and demethylated by methylesterase, a potent phosphatase methylesterase1 [169]

The NewcastleOttawa Scale consists of three main assessment categories: Selection (adequate definition of cases, representativeness of cases, selection of controls, definition of controls), Comparability (control for important factor or additional factor), and Exposure (ascertainment of exposure, same method of ascertainment for cases and rate controls, Non-Response rate)

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Ototoxicity resulting from cytostatic agents is often dose-dependent and may be exacerbated by concurrent administration of other ototoxic medications (Patatt et al

2025 ESMO Congress 36(2)