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Glutathione supplementation raises glutathione S-transferase activity, which does influence Phase II metabolism of other drugs, but because alendronate bypasses hepatic metabolism entirely, that pathway is irrelevant here

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However it remained unclear how this decision is made, and which genes and molecules are involved in this process

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*Correspondence: Roberto Badaro, [email protected];[email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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